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- A.K.Vidybida. Selectivity and sensitivity improvement in cooperative
system with a threshold in the presence of noise. J.theor.Biol., v.152, 1991, 159-164
Abstract. High selectivity (specificity) and sensitivity to natural and artificial stimuli which are normally observed in biological systems can be realized in an ensemble composed of many cooperatively connected primary receptors. The cooperative interaction results in the formation of several stable states and a switching from one state to the another one is performed in a threshold manner. When any noise is absent, the ensemble with a threshold can ensure as high selectivity and sensitivity as desired. The presence of noise sets limits on the possible informational quality of a system because spontaneous switching will occur. The question: What advantage as regards selectivity and sensitivity can a cooperative system with a threshold have is considered quantitatively for a model chemical bistable system. As a result it is established that a cooperative system can have much higher selectivity and sensitivity than its individual primary receptors. A live example for the cytolytic T lyphocyte degranulation triggering is considered.